Optimal First-Line Therapy for Previously Untreated Chronic Lymphocytic Leukemia: The Case for Chemotherapy.
نویسنده
چکیده
The last 10 years of clinical investigation in chronic lymphocytic leukemia (CLL) have established the efficacy of front-line chemoimmunotherapy in inducing remission; improving progression-free survival (PFS); and, with the addition of anti-CD20 antibodies, improving overall survival (OS).[1-3] For fit patients, the optimal regimen has recently been confirmed to be fludarabine, cyclophosphamide, and rituximab (FCR), which yielded improvements in complete response (CR), minimal residual disease clearance (MRD negativity), and PFS co
منابع مشابه
Optimal First-Line Therapy for Previously Untreated Chronic Lymphocytic Leukemia: The Case for Kinase Inhibitors.
The traditional approach to therapy for previously untreated patients with chronic lymphocytic leukemia (CLL) has been chemoimmunotherapy programs (whether FCR [fludarabine, cyclophosphamide, rituximab], FR [fludarabine, rituximab], BR [bendamustine, rituximab], PCR [pentostatin, cyclophosphamide, rituximab], other. These combination treatments have led to increased rates of clinical remission,...
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عنوان ژورنال:
- Oncology
دوره 29 6 شماره
صفحات -
تاریخ انتشار 2015